Article
Genome-wide CRISPR-Cas9 screen reveals a persistent null-hyphal phenotype that maintains high carotenoid production in Yarrowia lipolytica.
Biotechnology and bioengineering - 1 Dec 2022
Lupish Brian, Hall Jordan, Schwartz Cory, Ramesh Adithya, Morrison Clifford, Wheeldon Ian
Abstract excerpt
Yarrowia lipolytica is a metabolic engineering host of growing industrial interest due to its ability to metabolize hydrocarbons, fatty acids, glycerol, and other renewable carbon sources. This dimorphic yeast undergoes a stress-induced transition to a multicellular hyphal state, which can negatively impact biosynthetic activity, reduce oxygen and nutrient mass transfer in cell cultures, and increase culture...
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