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Article

Combining adaptive laboratory evolution and metabolic engineering for efficient erythritol production from crude glycerol by Yarrowia lipolytica.

Journal of biotechnology - 1 Nov 2026

Zhao Ling-Xuan, Li Jiawei, Wang Ya-Ting, Zhu Qin-Yi, Chen Jun, Liu Zhi-Jie, Liu Feng, Hua Qiang

Abstract excerpt

Erythritol is a natural zero-calorie sweetener with potential for sustainable healthy diets. While yeasts can convert biodiesel-derived glycerol into erythritol, the low production and by-product accumulation limit its industrial commercialization. Here, we isolated different morphologically Yarrowia lipolytica mutants with higher erythritol production through adaptive laboratory evolution under hyperosmotic...

Read the complete abstract on PubMed

Topics

Erythritol
Yarrowia
Glycerol
Metabolic Engineering
Fermentation
Bioreactors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Directed Molecular Evolution

Mutation

Source

Identifiers

PMID: 42633822
DOI: 10.1016/j.jbiotec.2026.08.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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