Article
Putamen Structure and Function in Familial Risk for Depression: A Multimodal Imaging Study.
Biological psychiatry - 15 Dec 2022
Talati Ardesheer, van Dijk Milenna T, Pan Lifang, Hao Xuejun, Wang Zhishun, Gameroff Marc, Dong Zhengchao, Kayser Jürgen, Shankman Stewart, Wickramaratne Priya J, Posner Jonathan, Weissman Myrna M
Abstract excerpt
BACKGROUND: The putamen has been implicated in depressive disorders, but how its structure and function increase depression risk is not clearly understood. Here, we examined how putamen volume, neuronal density, and mood-modulated functional activity relate to family history and prospective course of depression. METHODS: The study includes 115 second- and third-generation offspring at high or low risk for...
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