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Article

Tau‐induced deficits in nonsense‐mediated mRNA decay contribute to neurodegeneration

13 Apr 2022

Abstract excerpt

INTRODUCTION: While brains of patients with Alzheimer's disease and related tauopathies have evidence of altered RNA processing, we lack a mechanistic understanding of how altered RNA processing arises in these disorders and if such changes are causally linked to neurodegeneration. METHODS: Using Drosophila melanogaster models of tauopathy, we find that overall activity of nonsense-mediated mRNA decay (NMD), a...

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PMID: 35416419
DOI: 10.1002/alz.12653

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