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Article

Postnatal Foxp2 regulates early psychiatric-like phenotypes and associated molecular alterations in the R6/1 transgenic mouse model of Huntington's disease.

Neurobiology of disease - 15 Oct 2022

Rodríguez-Urgellés Ened, Rodríguez-Navarro Irene, Ballasch Iván, Del Toro Daniel, Del Castillo Ignacio, Brito Verónica, Alberch Jordi, Giralt Albert

Abstract excerpt

Huntington's Disease (HD) is a devastating disorder characterized by a triad of motor, psychiatric and cognitive manifestations. Psychiatric and emotional symptoms appear at early stages of the disease which are consistently described by patients and caregivers among the most disabling. Here, we show for the first time that Foxp2 is strongly associated with some psychiatric-like disturbances in the R6/1 mouse...

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Identifiers

PMID: 36029989
DOI: 10.1016/j.nbd.2022.105854

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