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Article

Temporal expression and mitochondrial localization of a Foxp2 isoform lacking the forkhead domain in developing Purkinje cells.

Journal of neurochemistry - 1 Jul 2012

Tanabe Yuko, Fujiwara Yuji, Matsuzaki Ayumi, Fujita Eriko, Kasahara Tadashi, Yuasa Shigeki, Momoi Takashi

Abstract excerpt

FOXP2, a forkhead box-containing transcription factor, forms homo- or hetero-dimers with FOXP family members and localizes to the nucleus, while FOXP2(R553H), which contains a mutation related to speech/language disorders, features reduced DNA binding activity and both cytoplasmic and nuclear localization. In addition to being a loss-of-function mutation, it is possible that FOXP2(R553H) also may act as a...

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Identifiers

PMID: 21985339
DOI: 10.1111/j.1471-4159.2011.07524.x

Genes

FOXP2

Variants

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