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Article

Exploring synthetic lethal network for the precision treatment of clear cell renal cell carcinoma.

Scientific reports - 2 Aug 2022

Liu Zhicheng, Lin Dongxu, Zhou Yi, Zhang Linmeng, Yang Chen, Guo Bin, Xia Feng, Li Yan, Chen Danyang, Wang Cun, Chen Zhong, Leng Chao, Xiao Zhenyu

Abstract excerpt

The emerging targeted therapies have revolutionized the treatment of advanced clear cell renal cell carcinoma (ccRCC) over the past 15 years. Nevertheless, lack of personalized treatment limits the development of effective clinical guidelines and improvement of patient prognosis. In this study, large-scale genomic profiles from ccRCC cohorts were explored for integrative analysis. A credible method was developed...

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Identifiers

PMID: 35918352
DOI: 10.1038/s41598-022-16657-7
PMCID: PMC9345903

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