Article
Loss of ALK hotspot mutations in relapsed neuroblastoma.
Genes, chromosomes & cancer - 1 Dec 2022
Allinson Lisa M, Potts Aaron, Goodman Angharad, Bown Nick, Bashton Matthew, Thompson Dean, Basta Nermine O, Gabriel Alem S, McCorkindale Michael, Ng Antony, McNally Richard J Q, Tweddle Deborah A
Abstract excerpt
ALK is the most commonly mutated oncogene in neuroblastoma with increased mutation frequency reported at relapse. Here we report the loss of an ALK mutation in two patients at relapse and a paired neuroblastoma cell line at relapse. ALK detection methods including Sanger sequencing, targeted next-generation sequencing and a new ALK Agena MassARRAY technique were used to detect common hotspot ALK variants in...
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