Article
Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome.
PLoS genetics - 1 Dec 2016
Padovan-Merhar Olivia M, Raman Pichai, Ostrovnaya Irina, Kalletla Karthik, Rubnitz Kaitlyn R, Sanford Eric M, Ali Siraj M, Miller Vincent A, Mossé Yael P, Granger Meaghan P, Weiss Brian, Maris John M, Modak Shakeel
Abstract excerpt
Neuroblastoma is characterized by a relative paucity of recurrent somatic mutations at diagnosis. However, recent studies have shown that the mutational burden increases at relapse, likely as a result of clonal evolution of mutation-carrying cells during primary treatment. To inform the development of personalized therapies, we sought to further define the frequency of potentially actionable mutations in...
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