Article
High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2010
Carr-Wilkinson Jane, O'Toole Kieran, Wood Katrina M, Challen Christine C, Baker Angela G, Board Julian R, Evans Laura, Cole Michael, Cheung Nai-Kong V, Boos Joachim, Köhler Gabriele, Leuschner Ivo, Pearson Andrew D J, Lunec John, Tweddle Deborah A
Abstract excerpt
PURPOSE: Most neuroblastomas initially respond to therapy but many relapse with chemoresistant disease. p53 mutations are rare in diagnostic neuroblastomas, but we have previously reported inactivation of the p53/MDM2/p14(ARF) pathway in 9 of 17 (53%) neuroblastoma cell lines established at relapse. HYPOTHESIS: Inactivation of the p53/MDM2/p14(ARF) pathway develops during treatment and contributes to...
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