Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men.

doi:10.1093/hmg/ddac214

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Article

Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men.

Human molecular genetics - 13 Jan 2023

Wang Anqi, Xu Yili, Yu Yao, Nead Kevin T, Kim TaeBeom, Xu Keren, Dadaev Tokhir, Saunders Ed, Sheng Xin, Wan Peggy, Pooler Loreall, Xia Lucy Y, Chanock Stephen, Berndt Sonja I, Gapstur Susan M, Stevens Victoria, Albanes Demetrius, Weinstein Stephanie J, Gnanapragasam Vincent, Giles Graham G, Nguyen-Dumont Tu, Milne Roger L, Pomerantz Mark M, Schmidt Julie A, Stopsack Konrad H, Mucci Lorelei A, Catalona William J, Hetrick Kurt N, Doheny Kimberly F, MacInnis Robert J, Southey Melissa C, Eeles Rosalind A, Wiklund Fredrik, Kote-Jarai Zsofia, de Smith Adam J, Conti David V, Huff Chad, Haiman Christopher A, Darst Burcu F

Abstract excerpt

Little is known regarding the potential relationship between clonal hematopoiesis (CH) of indeterminate potential (CHIP), which is the expansion of hematopoietic stem cells with somatic mutations, and risk of prostate cancer, the fifth leading cause of cancer death of men worldwide. We evaluated the association of age-related CHIP with overall and aggressive prostate cancer risk in two large whole-exome...

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Identifiers

PMID: 36018819
DOI: 10.1093/hmg/ddac214
PMCID: PMC9851740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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