Article
Modeling long-QT syndromes with iPS cells.
Journal of cardiovascular translational research - 1 Feb 2013
Sinnecker Daniel, Goedel Alexander, Dorn Tatjana, Dirschinger Ralf J, Moretti Alessandra, Laugwitz Karl-Ludwig
Abstract excerpt
The generation of induced pluripotent stem cells (iPSC) from human somatic cells bears the possibility to generate patient-specific stem cell lines which can serve as a theoretically unlimited source of somatic cells carrying the genotype of the patients. Different types of the long-QT syndrome have been studied by analyzing the phenotype of cardiomyocytes generated from patient-specific iPSC lines. Major aspects...
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