Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling genetic cardiac channelopathies using induced pluripotent stem cells - Status quo from an electrophysiological perspective.

Biochemical pharmacology - 1 Oct 2021

Kamga Michelle Vanessa Kapchoup, Reppel Michael, Hescheler Jürgen, Nguemo Filomain

Abstract excerpt

Long QT syndrome (LQTS), Brugada syndrome (BrS), and catecholaminergic polymorphic ventricular tachycardia (CPVT) are genetic diseases of the heart caused by mutations in specific cardiac ion channels and are characterized by paroxysmal arrhythmias, which can deteriorate into ventricular fibrillation. In LQTS3 and BrS different mutations in the SCN5A gene lead to a gain-or a loss-of-function of the voltage-gated...

Topics

Animals
Channelopathies
Electrophysiological Phenomena
Heart Diseases
Humans
Induced Pluripotent Stem Cells
Mutation
Myocytes, Cardiac

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34461117
DOI: 10.1016/j.bcp.2021.114746

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34461117-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling genetic cardiac channelopathies using induced pluripotent stem cells - Status quo from an electrophysiological perspective.PMID 34461117Read ↗

Modeling long QT syndromes using induced pluripotent stem cells: current progress and future challenges.Semantic proximity Read ↗

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmiasSemantic proximity Read ↗

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as Models for Cardiac ChannelopathiesSemantic proximity Read ↗

Modeling Inherited Cardiac DisordersSemantic proximity Read ↗

Modeling long-QT syndromes with iPS cells.Semantic proximity Read ↗

Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for modeling cardiac arrhythmias: strengths, challenges and potential solutionsSemantic proximity Read ↗

Cardiomyocytes Obtained From Induced Pluripotent Stem Cells With Long-QT Syndrome 3 Recapitulate Typical Disease-Specific Features In VitroSemantic proximity Read ↗

Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells.Semantic proximity Read ↗

Modelling the long QT syndrome with induced pluripotent stem cells.Semantic proximity Read ↗

Induced Pluripotent Stem Cell–Derived CardiomyocytesSemantic proximity Read ↗

The Disease-Specific Phenotype in Cardiomyocytes Derived from Induced Pluripotent Stem Cells of Two Long QT Syndrome Type 3 PatientsSemantic proximity Read ↗

Precision medicine for long QT syndrome: patient-specific iPSCs take the lead.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.