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Article

Genomic imprinting determines methylation of parental alleles in transgenic mice.

Nature - 1 Jan 2000

Reik W, Collick A, Norris M L, Barton S C, Surani M A

Abstract excerpt

Mouse embryogenesis relies on the presence of both the maternal and the paternal genome for development to term. It has been proposed that specific modifications are imprinted onto the chromosomes during gametogenesis; these modifications are stably propagated, and their expression results in distinct and complementary contributions of the two parental genomes to the development of the embryo and the...

Topics

Alleles
Animals
DNA
Gene Expression Regulation
Germ Cells
Methylation
Mice
Transfection

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 3600805
DOI: 10.1038/328248a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3600805-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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