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Article

Lamina-Associated Polypeptide 2α Loss Impairs Heart Function and Stress Response in Mice

20 Nov 2009

Abstract excerpt

RATIONALE: Lamina-associated polypeptide (LAP)2alpha is a mammalian chromatin-binding protein that interacts with a fraction of A-type lamins in the nuclear interior. Because mutations in lamins and LAP2alpha lead to cardiac disorders in humans, we hypothesized that these factors may play important roles in heart development and adult tissue homeostasis. OBJECTIVE: We asked whether the presence of LAP2alpha was...

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PMID: 19926876
DOI: 10.1161/circresaha.109.205724

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