Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR).

Current medicinal chemistry. Anti-cancer agents - 1 Jan 2004

Lee Chow H

Abstract excerpt

One of the main reasons for the failure in cancer chemotherapy is the existence of multidrug resistance (MDR) mechanisms. One form of MDR phenotype is contributed by a group of plasma membrane proteins that belong to a large superfamily of proteins called the ATP-binding cassette (ABC) transporters. There has been intense search for compounds, which can act at reversing MDR phenotype exhibited by ABC transporters...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ATP-Binding Cassette Transporters

Share to Drug Resistance, Multiple

Share to Drug Resistance, Neoplasm

Share to Phenotype

Source

Identifiers

PMID: 14754411
DOI: 10.2174/1568011043482197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug resistance (MDR).PMID 14754411Read ↗

Overcoming multidrug resistance through targeting ABC transporters: lessons for drug discoverySemantic proximity Read ↗

Small‐molecule inhibitors of multidrug resistance‐associated protein 1 and related processes: A historic approach and recent advancesSemantic proximity Read ↗

The Functions and Structure of ABC Transporters: Implications for the Design of New Inhibitors of Pgp and MRP1 to Control Multidrug Resistance (MDR)Semantic proximity Read ↗

Clinically-Relevant ABC Transporter for Anti-Cancer Drug ResistanceSemantic proximity Read ↗

Revisiting the ABCs of Multidrug Resistance in Cancer ChemotherapySemantic proximity Read ↗

Mechanism of multidrug resistance to chemotherapy mediated by P‑glycoprotein (Review)Semantic proximity Read ↗

New Approaches With Natural Product Drugs for Overcoming Multidrug Resistance in CancerSemantic proximity Read ↗

ABC Transporter Inhibitors in Reversing Multidrug Resistance to ChemotherapySemantic proximity Read ↗

ATP‐binding cassette (ABC) transporters in cancer: A review of recent updatesSemantic proximity Read ↗

How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?Semantic proximity Read ↗

Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)Semantic proximity Read ↗

Mechanisms and strategies to overcome multiple drug resistance in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.