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Paternally inherited H3K27me3 affects chromatin accessibility in mouse embryos produced by round spermatid injection

22 Aug 2022

Abstract excerpt

Round spermatid injection (ROSI) results in a lower birth rate than intracytoplasmic sperm injection, which has hampered its clinical application. Inefficient development of ROSI embryos has been attributed to epigenetic abnormalities. However, the chromatin-based mechanism that underpins the low birth rate in ROSI remains to be determined. Here, we show that a repressive histone mark, H3K27me3, persists from...

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PMID: 35993297
DOI: 10.1242/dev.200696

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