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Article

Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome

6 Jan 2022

Abstract excerpt

BACKGROUND: Paternal lifestyle choices and male exposure history have a critical influence on the health and fitness of the next generation. Accordingly, defining the processes of germline programming is essential to resolving how the epigenetic memory of paternal experiences transmits to their offspring. Established dogma holds that all facets of chromatin organization and histone posttranslational modification...

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PMID: 34991687
DOI: 10.1186/s13072-021-00433-4

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