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Single-cell multiomics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection

10 Aug 2022

Abstract excerpt

Round spermatid injection (ROSI) technique holds great promise for clinical treatment of a proportion of infertile men. However, the compromised developmental potential of ROSI embryos largely limits the clinical application, and the mechanisms are not fully understood. Here, we describe the transcriptome, chromatin accessibility, and DNA methylation landscapes of mouse ROSI embryos derived from early-stage round...

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PMID: 35947654
DOI: 10.1126/sciadv.abm3976

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