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Identification and validation of a miRNA-related expression signature for tumor mutational burden in colorectal cancer

20 Feb 2021

Abstract excerpt

BACKGROUND: Tumor mutational burden (TMB) is a promising predictor, which could stratify colorectal cancer (CRC) patients based on the response to immune checkpoint inhibitors (ICIs). MicroRNAs (miRNAs) act as the key regulators of anti-cancer immune response. However, the relationship between TMB and miRNA expression profiles is not elucidated in CRC. METHODS: group were identified for the CRC cohort of the TCGA...

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PMID: 33610190
DOI: 10.1186/s12957-021-02137-1

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