Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

14 Jan 2015

Abstract excerpt

Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are characterized by the following hallmarks: (a) An exponential increase with age; (b) Selective neuronal vulnerability; (c) Inverse cancer comorbidity. The present article appeals to these hallmarks to evaluate and contrast two competing models of AD: the amyloid hypothesis (a neuron-centric mechanism) and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Bioinformatics and Genomic Networks
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25642192
DOI: 10.3389/fphys.2014.00522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effectPMID 25642192Read ↗

Alzheimer's as a metabolic disease.Semantic proximity Read ↗

The inverse association of cancer and Alzheimer's: a bioenergetic mechanismSemantic proximity Read ↗

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunitiesSemantic proximity Read ↗

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer's disease.Semantic proximity Read ↗

Mitochondria-Targeted Therapeutics for Alzheimer's Disease: The Good, the Bad, the PotentialSemantic proximity Read ↗

Amyloid Beta: The Alternate HypothesisSemantic proximity Read ↗

Alzheimer’s disease: as it was in the beginningSemantic proximity Read ↗

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's DiseaseSemantic proximity Read ↗

The Alzheimer's disease mitochondrial cascade hypothesis: An updateSemantic proximity Read ↗

The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalkSemantic proximity Read ↗

Disentangling Mitochondria in Alzheimer’s DiseaseSemantic proximity Read ↗

The Alzheimer’s Disease Mitochondrial Cascade Hypothesis: A Current OverviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.