Article
Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts.
Communications biology - 17 Aug 2022
Brojakowska Agnieszka, Kour Anupreet, Thel Mark Charles, Park Eunbee, Bisserier Malik, Garikipati Venkata Naga Srikanth, Hadri Lahouaria, Mills Paul J, Walsh Kenneth, Goukassian David A
Abstract excerpt
With planned deep space and commercial spaceflights, gaps remain to address health risks in astronauts. Multiple studies have shown associations between clonal expansion of hematopoietic cells with hematopoietic malignancies and cardiometabolic disease. This expansion of clones in the absence of overt hematopoietic disorders is termed clonal hematopoiesis (CH) of indeterminate potential (CHIP). Using deep,...
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