Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis.

doi:10.1038/s41375-018-0047-7

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Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis.

Leukemia - 1 Sept 2018

Arends Christopher Maximilian, Galan-Sousa Joel, Hoyer Kaja, Chan Willy, Jäger Marten, Yoshida Kenichi, Seemann Ricarda, Noerenberg Daniel, Waldhueter Nils, Fleischer-Notter Helga, Christen Friederike, Schmitt Clemens A, Dörken Bernd, Pelzer Uwe, Sinn Marianne, Zemojtel Tomasz, Ogawa Seishi, Märdian Sven, Schreiber Adrian, Kunitz Annegret, Krüger Ulrike, Bullinger Lars, Mylonas Elena, Frick Mareike, Damm Frederik

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) occurs in an age-related manner and associates with an increased risk of hematologic cancer, atherosclerotic disease, and shorter overall survival. Little is known about the cell of origin, repartition patterns of clonal mutations within the hematopoietic differentiation tree, and its dynamics under evolutionary pressure. Using targeted sequencing, CHIP was...

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PMID: 29491455
DOI: 10.1038/s41375-018-0047-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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