Article
Clonal Hematopoiesis Before, During, and After Human Spaceflight.
Cell reports - 8 Dec 2020
Mencia-Trinchant Nuria, MacKay Matthew J, Chin Christopher, Afshinnekoo Ebrahim, Foox Jonathan, Meydan Cem, Butler Daniel, Mozsary Christopher, Vernice Nicholas A, Darby Charlotte, Schatz Michael C, Bailey Susan M, Melnick Ari M, Guzman Monica L, Bolton Kelly, Braunstein Lior Z, Garrett-Bakelman Francine, Levine Ross L, Hassane Duane C, Mason Christopher E
Abstract excerpt
Clonal hematopoiesis (CH) occurs when blood cells harboring an advantageous mutation propagate faster than others. These mutations confer a risk for hematological cancers and cardiovascular disease. Here, we analyze CH in blood samples from a pair of twin astronauts over 4 years in bulk and fractionated cell populations using a targeted CH panel, linked-read whole-genome sequencing, and deep RNA sequencing. We...
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