Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA.

mBio - 26 Oct 2022

Shema Mugisha Christian, Dinh Tung, Kumar Abhishek, Tenneti Kasyap, Eschbach Jenna E, Davis Keanu, Gifford Robert, Kvaratskhelia Mamuka, Kutluay Sebla B

Abstract excerpt

HIV-1 integrase (IN) has a noncatalytic function in virion maturation through its binding to the viral RNA genome (gRNA). Class II IN substitutions inhibit IN-gRNA binding and result in the formation of virions with aberrant morphologies marked by mislocalization of the gRNA between the capsid lattice and the lipid envelope. These viruses are noninfectious due to a block at an early reverse transcription stage in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Genomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipids

Share to RNA, Viral

Share to Static Electricity

Share to Virion

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 35975921
DOI: 10.1128/mbio.00431-22
PMCID: PMC9601147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA.PMID 35975921Read ↗

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.Semantic proximity Read ↗

A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor.Semantic proximity Read ↗

Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion MorphogenesisSemantic proximity Read ↗

Sequential Deletion of the Integrase (Gag-Pol) Carboxyl Terminus Reveals Distinct Phenotypic Classes of Defective HIV-1Semantic proximity Read ↗

Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.Semantic proximity Read ↗

Multimodal Functionalities of HIV-1 IntegraseSemantic proximity Read ↗

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residuesSemantic proximity Read ↗

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeatsSemantic proximity Read ↗

Genetic Analyses of Conserved Residues in the Carboxyl-Terminal Domain of Human Immunodeficiency Virus Type 1 IntegraseSemantic proximity Read ↗

Mutational scan of the human immunodeficiency virus type 2 integrase protein.Semantic proximity Read ↗

Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription ComplexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.