Article

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats

2021-01-12

Abstract excerpt

Retroviruses utilize the viral integrase (IN) protein to integrate a DNA copy of their genome into the host chromosomal DNA. HIV-1 integration sites are highly biased towards actively transcribed genes, likely mediated by binding of the IN protein to specific host factors, particularly LEDGF, located at these gene regions. We here report a dramatic redirection of integration site distribution induced by a single p...

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Literature Corpus work: f30cbe79-a789-57e8-9f8f-5377d0bfa3a2
DOI: 10.1101/2021.01.12.426369

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