Article
Genome-Wide 3'-UTR Single Nucleotide Polymorphism Association Study Identifies Significant Prostate Cancer Risk-Associated Functional Loci at 8p21.2 in Chinese Population.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2022
Zhang Ning, Huang Da, Jiang Guangliang, Chen Siteng, Ruan Xiaohao, Chen Haitao, Huang Jingyi, Liu Ao, Zhang Wenhui, Lin Xiaoling, Wu Yishuo, Zhang Qin, Li Jing, Tsu James Hok-Leung, Wei Gong-Hong, Na Rong
Abstract excerpt
MicroRNAs (miRNAs) are involved in the regulation of gene expression via incomplete base pairing to sequence motifs at the three prime untranslated regions (3'-UTRs) of mRNAs and play critical roles in the etiology of cancers. Single nucleotide polymorphisms (SNPs) in the 3'-UTR miRNA-binding regions may influence the miRNA affinity. However, this biological mechanism in prostate cancer (PCa) remains unclear....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.