A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression.

doi:10.1093/hmg/ddq350

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Article

A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression.

Human molecular genetics - 1 Nov 2010

Akamatsu Shusuke, Takata Ryo, Ashikawa Kyota, Hosono Naoya, Kamatani Naoyuki, Fujioka Tomoaki, Ogawa Osamu, Kubo Michiaki, Nakamura Yusuke, Nakagawa Hidewaki

Abstract excerpt

Genome-wide association studies (GWAS) identified multiple susceptible loci for prostate cancer (PC), and recent GWAS implicated that a common variant rs1512268 on chromosome 8p21 is associated with PC susceptibility, which is located at 14 kb downstream of a prostate tumor suppressor gene NKX3.1. To clarify a susceptibility gene and functional variants in this locus, we performed re-sequencing and fine mapping...

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PMID: 20716579
DOI: 10.1093/hmg/ddq350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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