Article
Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers.
Nucleic acids research - 1 Jan 2007
Yu Zhenbao, Li Zhen, Jolicoeur Normand, Zhang Linhua, Fortin Yves, Wang Edwin, Wu Meiqun, Shen Shi-Hsiang
Abstract excerpt
MicroRNAs (miRNAs) are a class of noncoding small RNAs that regulate gene expression by base pairing with target mRNAs at the 3'-terminal untranslated regions (3'-UTRs), leading to mRNA cleavage or translational repression. Single-nucleotide polymorphisms (SNPs) located at miRNA-binding sites (miRNA-binding SNPs) are likely to affect the expression of the miRNA target and may contribute to the susceptibility of...
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