Article
Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours.
The Journal of pathology - 1 Jan 2014
Parker Brittany C, Engels Manon, Annala Matti, Zhang Wei
Abstract excerpt
The emergence of fibroblast growth factor receptor (FGFR) family fusions across diverse cancers has brought attention to FGFR-derived cancer therapies. The discovery of the first recurrent FGFR fusion in glioblastoma was followed by discoveries of FGFR fusions in bladder, lung, breast, thyroid, oral, and prostate cancers. Drug targeting of FGFR fusions has shown promising results and should soon be translating...
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