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Article

Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs.

Acta neuropathologica communications - 14 Apr 2021

Georgescu Maria-Magdalena, Islam Mohammad Zahidul, Li Yan, Traylor James, Nanda Anil

Abstract excerpt

Prognostic molecular subgrouping of glioblastoma is an ongoing effort and the current classification includes IDH-wild-type and IDH-mutant entities, the latter showing significantly better prognosis. We performed a comparative integrated analysis of the FGFR glioblastoma subgroup consisting of 5 cases from a prospective 101-patient-cohort. FGFR alterations included FGFR2-TACC2 and FGFR2 amplifications arising in...

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Identifiers

PMID: 33853673
DOI: 10.1186/s40478-021-01170-1
PMCID: PMC8048363

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