Article
Substitution mutational signatures in whole-genome-sequenced cancers in the UK population.
Science (New York, N.Y.) - 22 Apr 2022
Degasperi Andrea, Zou Xueqing, Amarante Tauanne Dias, Martinez-Martinez Andrea, Koh Gene Ching Chiek, Dias João M L, Heskin Laura, Chmelova Lucia, Rinaldi Giuseppe, Wang Valerie Ya Wen, Nanda Arjun S, Bernstein Aaron, Momen Sophie E, Young Jamie, Perez-Gil Daniel, Memari Yasin, Badja Cherif, Shooter Scott, Czarnecki Jan, Brown Matthew A, Davies Helen R, Nik-Zainal Serena
Abstract excerpt
Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses, revealing mutational signatures, imprints of DNA damage and repair processes that have arisen in each patient's cancer. We performed mutational signature analyses on 12,222 WGS tumor-normal matched pairs, from patients recruited via the UK National Health Service. We contrasted our results to two independent cancer WGS datasets, the...
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