Article
Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction.
Cancer research communications - 1 Oct 2025
Burge Rachel A, Bialousow Lucas, McFall Thomas, Bamonte Logan, Johnson Grayson, Smith Merissa, Vaena Silvia G, Comte-Walters Susana, Ball Lauren E, Berto Stefano, O'Bryan John P, Hobbs G Aaron
Abstract excerpt
The RAS family of small GTPases is among the most frequently mutated gene families in human cancer. In pancreatic ductal adenocarcinoma (PDAC), ∼95% of cases harbor an activating KRAS mutation, primarily at codon 12, 13, or 61, with G12D being the most common overall (40%). In contrast, the KRASQ61L mutation, though constitutively active, is virtually absent in tumors of patients with PDAC. This suggests that...
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