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Article

miR-196b-TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Oct 2022

Gamlen Holly A, Romer-Seibert Jennifer S, Lawler Michael E, Versace Amanda M, Goetz Melanie L, Feng Yang, Guryanova Olga A, Palmisiano Neil, Meyer Sara E

Abstract excerpt

PURPOSE: DNMT3A mutations confer a poor prognosis in acute myeloid leukemia (AML), but the molecular mechanisms downstream of DNMT3A mutations in disease pathogenesis are not completely understood, limiting targeted therapeutic options. The role of miRNA in DNMT3A-mutant AML pathogenesis is understudied. EXPERIMENTAL DESIGN: DNA methylation and miRNA expression was evaluated in human AML patient samples and in...

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Share to DNA (Cytosine-5-)-Methyltransferases
Share to DNA Methyltransferase 3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Modification Methylases

Share to Immunity, Innate

Share to Leukemia, Myeloid, Acute

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Identifiers

PMID: 35943291
DOI: 10.1158/1078-0432.CCR-22-1598
PMCID: PMC9588567

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