Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential

11 Jul 2018

Abstract excerpt

We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. Here, we used an shRNA screening approach to mimic miRNA activity on experimentally verified miR-196b targets to identify functionally important and therapeutically relevant pathways downstream of oncogenic miRNA in MLL-r AML. We found Cdkn1b (p27Kip1) is a direct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to MicroRNA in disease regulation
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29997117
DOI: 10.1084/jem.20171312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potentialPMID 29997117Read ↗

miR-194-5p/BCLAF1 deregulation in AML tumorigenesisSemantic proximity Read ↗

miR-196b-TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML.Semantic proximity Read ↗

PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic LeukemiaSemantic proximity Read ↗

High level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcomeSemantic proximity Read ↗

Targeting IGF2BP3 enhances antileukemic effects of menin-MLL inhibition in MLL-AF4 leukemiaSemantic proximity Read ↗

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem CellsSemantic proximity Read ↗

The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiationSemantic proximity Read ↗

The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemiaSemantic proximity Read ↗

Lyn Kinase-Dependent Regulation of miR181 and Myeloid Cell Leukemia-1 Expression: Implications for Drug Resistance in Myelogenous LeukemiaSemantic proximity Read ↗

Tyrosine kinase inhibitor–induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signalingSemantic proximity Read ↗

miR-30e-5p regulates leukemia stem cell self-renewal through the Cyb561/ROS signaling pathwaySemantic proximity Read ↗

Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.