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Article

Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences

16 Apr 2019

Abstract excerpt

Serine/arginine-rich splicing factor 2 (SRSF2) is a member of the SR protein family that is involved in both constitutive and alternative mRNA splicing. Mutations in SRSF2 gene were frequently reported in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It is imperative how these mutations affect SRSF2-mediated splicing and cause MDS. In this study, we tried to characterize SRSF2 mutants (P95H,...

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PMID: 31040863
DOI: 10.3389/fgene.2019.00338

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