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Article

Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: prevalence, clinical correlates, and prognostic relevance.

American journal of hematology - 1 Mar 2013

Patnaik Mrinal M, Lasho Terra L, Finke Christy M, Hanson Curtis A, Hodnefield Janice M, Knudson Ryan A, Ketterling Rhett P, Pardanani Animesh, Tefferi Ayalew

Abstract excerpt

SRSF2, SF3B1, and U2AF35 (U2AF1) are the three most frequent genes involved with spliceosome mutations in myeloid malignancies. SF3B1 mutations are most frequent (~80%) in myelodysplastic syndromes (MDS) with ring sideroblasts (RS) but lack prognostic relevance. SRSF2 mutations are associated with shortened overall (OS) and leukemia-free survival (LFS) in both MDS and myelofibrosis. In this study of 226 patients...

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Share to Leukemia, Myelomonocytic, Chronic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribonucleoprotein, U2 Small Nuclear

Share to Ribonucleoproteins

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Share to Serine-Arginine Splicing Factors

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Source

Identifiers

PMID: 23335386
DOI: 10.1002/ajh.23373

Genes

SRSF2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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