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Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis

2025-06-09

Abstract excerpt

Flaviviruses such as dengue and Zika viruses extensively remodel host cell membranes to create specialised replication organelles, but the role of lipid metabolism to generate them remain poorly understood. Through systematic screens of fatty acyl transferase enzymes (MBOAT and zDHHC families) and complementary approaches including CRISPR/Cas9 gene deletions, pharmacological inhibition, proteomics, and photo-cross...

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Literature Corpus work
afbec3fc-bb73-5026-ac8c-340260822c32
DOI
10.1101/2025.06.07.658178
Open publication

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Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesisDOI 10.1101/2025.06.07.658178
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