Article

A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

2022-12-10

Abstract excerpt

Host-based antivirals could offer broad-spectrum therapeutics and prophylactics against the constantly-mutating viruses including the currently-ravaging coronavirus, yet must target cellular vulnerabilities of viruses without grossly endangering the host. Here we show that the master lipid regulator SREBP1 couples the phospholipid scramblase TMEM41B to constitute a host “metabolism-to-manufacture” cascade that max...

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Literature Corpus work: 783f5feb-82ab-5a19-ac36-b89fa32d68db
DOI: 10.1101/2022.12.07.519404

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