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Dengue Virus and Autophagy

4 Aug 2011

Abstract excerpt

Several independent groups have published that autophagy is required for optimal RNA replication of dengue virus (DENV). Initially, it was postulated that autophagosomes might play a structural role in replication complex formation. However, cryo-EM tomography of DENV replication complexes showed that DENV replicates on endoplasmic reticulum (ER) cisternae invaginations and not on classical autophagosomes....

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PMID: 21994782
DOI: 10.3390/v3081332

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