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Article

The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes.

Frontiers in immunology - 1 Jan 2022

Rojas Manuel, Heuer Luke S, Zhang Weici, Chen Yi-Guang, Ridgway William M

Abstract excerpt

Autoimmunity involves a loss of immune tolerance to self-proteins due to a combination of genetic susceptibility and environmental provocation, which generates autoreactive T and B cells. Genetic susceptibility affects lymphocyte autoreactivity at the level of central tolerance (e.g., defective, or incomplete MHC-mediated negative selection of self-reactive T cells) and peripheral tolerance (e.g., failure of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35935980
DOI: 10.3389/fimmu.2022.918837
PMCID: PMC9353112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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