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Article

Epigenetic focus on angioimmunoblastic T-cell lymphoma: pathogenesis and treatment

6 Jul 2021

Abstract excerpt

PURPOSE OF REVIEW: Angioimmunoblastic T-cell lymphoma (AITL) is a frequent peripheral T-cell lymphoma affecting elderly patients with a poor outcome when treated with conventional chemotherapy. Molecular studies revealed a homogenous mutational landscape gathering anomalies in genes regulating the DNA methylation and hydroxymethylation and anomalies in T-cell signalling. RECENT FINDINGS: Recent studies indicate...

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PMID: 34230442
DOI: 10.1097/cco.0000000000000773

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