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Article

Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis.

The Journal of clinical investigation - 1 Aug 2017

Zang Shengbing, Li Jia, Yang Haiyan, Zeng Hongxiang, Han Wei, Zhang Jixiang, Lee Minjung, Moczygemba Margie, Isgandarova Sevinj, Yang Yaling, Zhou Yubin, Rao Anjana, You M James, Sun Deqiang, Huang Yun

Abstract excerpt

Angioimmunoblastic T cell lymphoma (AITL) represents a distinct, aggressive form of peripheral T cell lymphoma with a dismal prognosis. Recent exome sequencing in patients with AITL has revealed the frequent coexistence of somatic mutations in the Rho GTPase RhoA (RhoAG17V) and loss-of-function mutations in the 5-methylcytosine oxidase TET2. Here, we have demonstrated that TET2 loss and RhoAG17V expression in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28691928
DOI: 10.1172/JCI92026
PMCID: PMC5531410

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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