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Article

DNMT3AR882H accelerates angioimmunoblastic T-cell lymphoma in mice.

Oncogene - 1 Jun 2023

Zheng Jianan, Wang Zhongwang, Pan Xiangyu, Zhang Zhixin, Li He, Deng Xintong, Liu Pengpeng, Zhang Qi, Na Feifei, Chen Chong, Niu Ting, Liu Yu

Abstract excerpt

DNA methylation-related genes, including TET2, IDH2, and DNMT3A are highly frequently mutated in angioimmunoblastic T-cell lymphoma (AITL), an aggressive malignancy of T follicular helper (Tfh) cells associated with aberrant immune features. It has been shown that TET2 loss cooperates with RHOAG17V to promote AITL in mice but the functional role of DNMT3A mutations in AITL remains unclear. Here, we report that...

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Identifiers

PMID: 37127775
DOI: 10.1038/s41388-023-02699-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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