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Article

Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells.

Diabetologia - 1 Dec 2022

Portillo Jose-Andres C, Yu Jin-Sang, Vos Sarah, Bapputty Reena, Lopez Corcino Yalitza, Hubal Alyssa, Daw Jad, Arora Sahil, Sun Wenyu, Lu Zheng-Rong, Subauste Carlos S

Abstract excerpt

AIMS/HYPOTHESIS: CD40 expressed in Müller cells is a central driver of diabetic retinopathy. CD40 causes phospholipase Cγ1 (PLCγ1)-dependent ATP release in Müller cells followed by purinergic receptor (P2X7)-dependent production of proinflammatory cytokines in myeloid cells. In the diabetic retina, CD40 and P2X7 upregulate a broad range of inflammatory molecules that promote development of diabetic retinopathy....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 35920844
DOI: 10.1007/s00125-022-05775-6
PMCID: PMC9630214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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