Article

Caspase-8-mediated inflammation but not apoptosis drives death of retinal ganglion cells and loss of visual function in glaucomaa

2024-06-18

Abstract excerpt

<title>Abstract</title> <p>Background - Glaucoma is a complex multifactorial disease where apoptosis and inflammation represent two key pathogenic mechanisms. However, the relative contribution of apoptosis versus inflammation in axon degeneration and death of retinal ganglion cells (RGCs) is not well understood. In glaucoma, caspase-8 is linked to RGC apoptosis, as well as glial activation and neuroinflammation...

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Literature Corpus work: ee619e45-6d80-5788-8436-2c91c45d0609
DOI: 10.21203/rs.3.rs-4409426/v1

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