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Article

Differential role of Jak‐STAT signaling in retinal degenerations

11 Sept 2006

Abstract excerpt

Retinal degeneration is a major cause of severe visual impairment or blindness. Understanding the underlying molecular mechanisms is a prerequisite to develop therapeutic approaches for human patients. We show in three mouse models that induced and inherited retinal degeneration induces LIF and CLC as members of the interleukin (IL)-6 family of proteins, activates proteins of the Jak-STAT signaling pathway, and...

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PMID: 16966486
DOI: 10.1096/fj.06-5895fje

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