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Breast cancer in East Africa: Prevalence and spectrum of germline SNV/indel and CNVs in BRCA1 and BRCA2 genes among breast cancer patients in Tanzania.

Cancer medicine - 1 Feb 2023

Rweyemamu Linus P, Gültaşlar Büşra K, Akan Gokce, Dharsee Nazima, Namkinga Lucy A, Lyantagaye Sylvester L, Yazıcı Hülya, Atalar Fatmahan

Abstract excerpt

BACKGROUND: Growing prevalence and aggressiveness of breast cancer (BC) among East African women strongly indicate that the genetic risk factor implicated in the etiology of the disease may have a key role. Germline pathogenic variants in BRCA1 and BRCA2 (BRCA1/2) are known to increase the lifetime risk of BC. This study investigated the prevalence and spectrum of germline single nucleotide variant/insertion and...

Topics

Humans
Female
Genes, BRCA2
Breast Neoplasms
DNA Copy Number Variations
Tanzania
Prevalence
Genetic Predisposition to Disease
BRCA1 Protein
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Triple Negative Breast Neoplasms

BRCA2 Protein

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Open in PubMed Open full text

Identifiers

PMID: 35908255
DOI: 10.1002/cam4.5091
PMCID: PMC9939169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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