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Mutational spectrum of BRCA1/2 genes in Moroccan patients with hereditary breast and/or ovarian cancer, and review of BRCA mutations in the MENA region.

Breast cancer research and treatment - 1 Jul 2022

Elalaoui Siham Chafai, Laarabi Fatima Zohra, Afif Lamiae, Lyahyai Jaber, Ratbi Ilham, Jaouad Imane Cherkaoui, Doubaj Yassamine, Sahli Meryem, Ouhenach Mouna, Sefiani Abdelaziz

Abstract excerpt

PURPOSE: Breast cancer (BC) is the most common form of female cancer around the world. BC is mostly sporadic, and rarely hereditary. These hereditary forms are mostly BRCA1- and BRCA2-associated hereditary breast and ovarian cancer syndrome. BRCA1 and BRCA2 genes are large and had some recurrent mutations specific to some populations. Through this work we analyze the most recurrent mutations in Moroccan...

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PMID: 35578052
DOI: 10.1007/s10549-022-06622-3

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