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Article

Global prevalence and ethnic variation of pathogenic BRCA1/2 variants in breast cancer: a systematic review and meta-analysis.

Journal of translational medicine - 12 Mar 2026

Khan Najeeb Ullah, Lei Huijun, Fu Jinzhen, Lei Ruijiao, Chen Xukai, Alqarni Sana S, Chen Tianhui

Abstract excerpt

BACKGROUND: The breast cancer (BC) susceptibility genes 1 (BRCA1) and BC susceptibility genes 2 (BRCA2) are critical genes associated with hereditary breast cancer, and their mutation prevalence might greatly vary across different ethnic populations. This systematic review and meta-analysis evaluated global ethnic variation in BRCA1/2 mutation prevalence among breast cancer (BC) patients. METHODS: We searched...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41821042
DOI: 10.1186/s12967-026-07997-3
PMCID: PMC13097826

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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